Epidemiology and Burden of NMOSD, MS, and MOGAD in Thailand: a Population-Based Study

Objective To determine cumulative incidence and point prevalence of neuromyelitis optica spectrum disorder (NMOSD), multiple sclerosis (MS), myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) in Thailand using population-based data Chumphon province. Background CNS inflammatory demyelinating diseases (CNSIDDs) have a great interracial heterogeneity. The epidemiology CNSIDDs Thailand, Mainland Southeast Asian country, is unknown. Design/Methods Searching for CNSIDD patients at public secondary care hospital from January 2016 to December 2021 was performed relevant ICD-10-CM codes. All neurology were systematically referred this as it the only province with neurologist. Diagnoses individually ascertained by retrospective chart review. Cumulative over 2016-2021, on 31st, 2021, attack rate, mortality disability-adjusted life years (DALYs) calculated. Population obtained National Statistical Office Thailand. As population census 509,479. Results NMOSD most prevalent adult Thai 3.33 per 100,000 persons (crude 2.55). age-adjusted aquaporin-4 antibody-positive alone 3.08 persons. Age-adjusted rate 1.65 persons/year 0.20). MS followed 0.77 MOGAD 0.51 0.59 0.39, respectively). Although had fair recovery, disability worst among DALY 3.47 Mortality rates highest well. No increase or observed during COVID-19 pandemic. Conclusions are rare comparable that East countries. caused DALYs CNSIDDs.